NUPL1

Nucleoporin p58/p45 is a protein that in humans is encoded by the NUPL1 gene.

NUP58
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JO7, 4JO9, 4JQ5, 5IJN, 5IJO
Identifiers
Aliases	NUP58, PRO2463, NUPL1, NUP45, nucleoporin 58kDa, nucleoporin 58
External IDs	OMIM: 607615; MGI: 1919094; HomoloGene: 40924; GeneCards: NUP58; OMA:NUP58 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q12.13 Start 25,301,152 bp End 25,365,390 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D1 Start 60,442,731 bp End 60,488,956 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad Achilles tendon right testis testicle left testis ganglionic eminence ventricular zone monocyte anterior pituitary cartilage tissue Top expressed in cumulus cell condyle primitive streak hair follicle conjunctival fornix fossa Gonadal ridge ureter trigeminal ganglion Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear localization sequence binding structural constituent of nuclear pore Cellular component nuclear membrane nuclear envelope membrane nucleus nuclear pore protein-containing complex host cell Biological process mRNA transport protein heterotetramerization protein heterooligomerization nucleocytoplasmic transport regulation of protein import into nucleus protein transport viral process protein homooligomerization mRNA export from nucleus protein import into nucleus protein heterotrimerization regulation of glycolytic process tRNA export from nucleus protein sumoylation viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9818 71844 Ensembl ENSG00000139496 ENSMUSG00000114797 UniProt Q9BVL2 Q8R332 RefSeq (mRNA) NM_001008564 NM_001008565 NM_014089 NM_014778 NM_170591 NM_001362439 NM_001362440 RefSeq (protein) NP_001008564 NP_054808 NP_733479 NP_001349368 NP_001349369 Location (UCSC) Chr 13: 25.3 – 25.37 Mb Chr 14: 60.44 – 60.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC).

All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–61. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ben-Efraim I, Gerace L (2001). "Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMC 2199621. PMID 11266456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.