Nucleoporin p58/p45 is a protein that in humans is encoded by the NUPL1 gene.[5][6]

NUP58
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUP58, PRO2463, NUPL1, NUP45, nucleoporin 58kDa, nucleoporin 58
External IDsOMIM: 607615; MGI: 1919094; HomoloGene: 40924; GeneCards: NUP58; OMA:NUP58 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001008564
NM_001008565
NM_014089
NM_014778

NM_170591
NM_001362439
NM_001362440

RefSeq (protein)

NP_001008564
NP_054808

NP_733479
NP_001349368
NP_001349369

Location (UCSC)Chr 13: 25.3 – 25.37 MbChr 14: 60.44 – 60.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC).

All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139496Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000114797Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  6. ^ a b "Entrez Gene: NUPL1 nucleoporin like 1".

Further reading

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