NXPH1

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.

NXPH1
Identifiers
Aliases	NXPH1, NPH1, Nbla00697, neurexophilin 1
External IDs	OMIM: 604639; MGI: 107492; HomoloGene: 8284; GeneCards: NXPH1; OMA:NXPH1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p21.3 Start 8,433,609 bp End 8,752,961 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A1 Start 8,948,431 bp End 9,249,032 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex endothelial cell secondary oocyte prefrontal cortex testicle left adrenal gland left adrenal cortex hypothalamus cingulate gyrus anterior cingulate cortex Top expressed in lateral septal nucleus medial dorsal nucleus dorsomedial hypothalamic nucleus ventral tegmental area anterior amygdaloid area dorsal tegmental nucleus medial vestibular nucleus habenula lumbar subsegment of spinal cord ventromedial nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 30010 18231 Ensembl ENSG00000122584 ENSMUSG00000046178 UniProt P58417 Q61200 RefSeq (mRNA) NM_152745 NM_008751 RefSeq (protein) NP_689958 NP_032777 Location (UCSC) Chr 7: 8.43 – 8.75 Mb Chr 6: 8.95 – 9.25 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.

Further reading

• Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–68. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
• Petrenko AG, Ullrich B, Missler M, et al. (1996). "Structure and evolution of neurexophilin". J. Neurosci. 16 (14): 4360–9. doi:10.1523/JNEUROSCI.16-14-04360.1996. PMC 6578849. PMID 8699246.
• Missler M, Hammer RE, Südhof TC (1999). "Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit". J. Biol. Chem. 273 (52): 34716–34723. doi:10.1074/jbc.273.52.34716. PMID 9856994.
• Clarris HJ, McKeown S, Key B (2003). "Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb". Int. J. Dev. Biol. 46 (4): 649–52. PMID 12141453.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.