Najafi (Arabic: نجفي; Persian: نجفی) is a surname originating from Najaf (Arabic: نجف), Iraq. Notable people with the surname include:
- Abolhassan Najafi, Iranian writer
- Ayatollah Sheikh Basheer Hussain Najafi, Iraqi grand ayatollah
- Bagher Najafi, Iranian scholar
- Grand Ayatollah Muhammad Hussain Najafi, Pakistani grand ayatollah
- Hafiz Riaz Hussain Najafi, Pakistani educator
- Mohammad-Ali Najafi, Iranian politician
- Sina Najafi, American magazine editor
- Shahin Najafi, Iranian musician
- Syed Safdar Hussain Najafi, Pakistani scholar