Ncube or Mncube is a very common surname among the Matabele, Kalanga and Zulu people of Southern Africa.
Notable people with the surname include:
- Abedinico Ncube (born 1954), Zimbabwean ZANU-PF politician placed on the United States sanctions list.
- Andile Ncube (born 1981), South African television host of The X Factor SA.
- Lieutenant Colonel Ben Ncube (born 1959), spokesperson for the Zimbabwe National Army.
- Busi Ncube (born 1963), Zimbabwean singer and musician.
- Butholezwe Ncube (born 1992), Zimbabwean association footballer.
- Carl Joshua Ncube (born 1979), Zimbabwean stand-up comedian and television producer.
- Cunningham Ncube (born 1990), Zimbabwean cricketer.
- Fletcher Dulini Ncube (1940–2014), former Zimbabwean MDC politician.
- Gugulethu Zuma-Ncube (born 1985), daughter of former South African president Jacob Zuma and daughter-in-law of Welshman Ncube.
- Japhet Ndabeni Ncube, former Mayor of Bulawayo.
- Lancelot Ncube (born 1996), Zimbabwe-born Swedish actor.
- Mduduzi Ncube (born 1988 or 1989), South African singer-songwriter.
- Professor Mthuli Ncube (born 1963), former chief economist and vice president of the African Development Bank.
- Ndabenkulu Ncube (born 1988), Zimbabwean association footballer.
- Ngonidzashe Ncube (born 1986), Zimbabwean long-distance runner.
- Njabulo Ncube (born 1989), Zimbabwean cricketer.
- Nobukhosi Ncube (born 1993), Zimbabwean association footballer.
- Nomusa Dube-Ncube, South African ANC politician and former diplomat.
- Owen Ncube (born 1968), Zimbabwean ZANU-PF politician placed on the United States sanctions and UK sanctions lists.
- Pilan Ncube (born 1983), international association football referee from Zimbabwe.
- Pius Ncube (born 1946), disgraced former archbishop of Bulawayo.
- Raphael Macebo Mabuza Ncube (born 1973), Zimbabwean Catholic bishop.
- Sello Maake kaNcube (born 1963), South African actor.
- Sethulo Ncube, commissioner at the Zimbabwe Human Rights Commission.
- Sister Bernard Ncube (1932–2012), former mayor of the West Rand region of Johannesburg, South Africa.
- Trevor Ncube (born 1962), Zimbabwean editor and publisher.
- Professor Welshman Ncube (born 1961), legal scholar and politician.