The Romanian-language surname Negrescu is derived from the word negru, "black".
The surname may refer to:
- Igor Negrescu, Moldavian professional football manager and former footballer
- Ion Negrescu, Romanian politician
- Gheorghe Negrescu (1887 – 1977), Romanian general, a pioneer of Romanian aviation
- Pedro Negrescu (1969 – 2021), Romanian jazz double bassist and classical music conductor
- Radu Negrescu-Suțu , Romanian writer and anti-Communist militant
- William Pierpont Black, born Wilhelm Peter Negrescu, was a New Zealand wood carver, journal editor and publisher, journalist