NmsRA and NmsRB (Neisseria metabolic switch regulator), RcoF1 and RcoF2 (RNA regulating colonization factor) as well as NgncR_162 and NgncR_163 (Neisseria gonorrhoeae non-coding RNA) are all names of neisserial sibling small regulatory RNAs described and independently named in three publications.[1][2][3] NmsRB/RcoF1/NgncR_163 was shown to be the predominant sibling. The sRNAs are tandemly arranged, structurally nearly identical and share 70% sequence identity. They translationally down-regulate genes involved in basic metabolic processes including tricarboxylic acid cycle enzymes and amino acid uptake and degradation. The target genes include: fumC, sdhC, gltA, sucC, prpB and prpC.[2][3] The expression of the sRNAs is presumably under the control of RelA, as shown for N. meningitidis.[1] Furthermore, the sRNAs interact with Hfq protein and target repression of putative colonization factor of the human nasopharynx PrpB mRNA, hence one of the proposed names is RNA regulating colonization factor.[2]
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editReferences
edit- ^ a b Pannekoek Y, Huis In 't Veld RA, Schipper K, Bovenkerk S, Kramer G, Brouwer MC, van de Beek D, Speijer D, van der Ende A (March 2017). "Neisseria meningitidis Uses Sibling Small Regulatory RNAs To Switch from Cataplerotic to Anaplerotic Metabolism". American Society for Microbiology. 8 (2): e02293-16. doi:10.1128/mBio.02293-16. PMC 5362039. PMID 28325760.
- ^ a b c Heidrich N, Bauriedl S, Barquist L, Li L, Schoen C, Vogel J (June 2017). "The primary transcriptome of Neisseria meningitidis and its interaction with the RNA chaperone Hfq". Nucleic Acids Research. 45 (10): 6147–6167. doi:10.1093/nar/gkx168. PMC 5449619. PMID 28334889.
- ^ a b Bauer S, Helmreich J, Zachary M, Kaethner M, Heinrichs E, Rudel T, Beier D (November 2017). "The sibling sRNAs NgncR_162 and NgncR_163 of Neisseria gonorrhoeae participate in the expression control of metabolic, transport and regulatory proteins". Microbiology. 163 (11): 1720–1734. doi:10.1099/mic.0.000548. PMID 29058643.
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