Neopentalenolactone D synthase (EC 1.14.13.171, ptlE (gene)) is an enzyme with systematic name 1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (neopentalenolactone-D forming).[1] This enzyme catalyses the following chemical reaction
| Neopentalenolactone D synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.171 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 1-deoxy-11-oxopentalenate + NADPH + H+ + O2 neopentalenolactone D + NADP+ + H2O
Neopentalenolactone D synthase is a FAD-dependent oxygenase.
References
edit- ^ Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE (March 2011). "Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone". Biochemistry. 50 (10): 1739–54. doi:10.1021/bi1019786. PMC 3051010. PMID 21250661.
External links
edit- Neopentalenolactone+D+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
