Nephronectin

Nephronectin is a protein that in humans is encoded by the NPNT gene.

NPNT
Identifiers
Aliases	NPNT, EGFL6L, POEM, nephronectin
External IDs	OMIM: 610306; MGI: 2148811; HomoloGene: 14138; GeneCards: NPNT; OMA:NPNT - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q24 Start 105,894,775 bp End 106,004,027 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G3 Start 132,587,506 bp End 132,656,052 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right lung jejunal mucosa right coronary artery Descending thoracic aorta ascending aorta lower lobe of lung upper lobe of lung upper lobe of left lung Top expressed in ascending aorta epithelium of lens aortic valve left lung lobe tunica media of zone of aorta right lung lobe calvaria medullary collecting duct molar efferent ductule More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding integrin binding extracellular matrix structural constituent Cellular component membrane smooth muscle contractile fiber extracellular matrix integrin alpha8-beta1 complex extracellular region basement membrane extracellular exosome extracellular space collagen-containing extracellular matrix Biological process positive regulation of transforming growth factor beta receptor signaling pathway cell differentiation ureteric bud development establishment of protein localization cellular response to tumor necrosis factor extracellular matrix organization cell-cell adhesion mediated by integrin multicellular organism development branching involved in ureteric bud morphogenesis positive regulation of osteoblast differentiation cell adhesion pilomotor reflex positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation positive regulation of alkaline phosphatase activity positive regulation of ERK1 and ERK2 cascade cell-matrix adhesion positive regulation of smooth muscle contraction positive regulation of cell-substrate adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 255743 114249 Ensembl ENSG00000168743 ENSMUSG00000040998 UniProt Q6UXI9 Q91V88 RefSeq (mRNA) NM_001033047 NM_001184690 NM_001184691 NM_001184692 NM_001184693 NM_198278 NM_001029836 NM_001287101 NM_001287102 NM_001287103 NM_033525 RefSeq (protein) NP_001028219 NP_001171619 NP_001171620 NP_001171621 NP_001171622 NP_001025007 NP_001274030 NP_001274031 NP_001274032 NP_277060 Location (UCSC) Chr 4: 105.89 – 106 Mb Chr 3: 132.59 – 132.66 Mb PubMed search
Wikidata
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Further reading

• Kahai S, Lee SC, Lee DY, Yang J, Li M, Wang CH, Jiang Z, Zhang Y, Peng C, Yang BB (2009). "MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7". PLOS ONE. 4 (10): e7535. Bibcode:2009PLoSO...4.7535K. doi:10.1371/journal.pone.0007535. PMC 2760121. PMID 19844573.
• Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter JI, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BH, O'Connor GT, London SJ (2010). "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function". Nat. Genet. 42 (1): 45–52. doi:10.1038/ng.500. PMC 2832852. PMID 20010835.
• Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
• Nakatani S, Wei M, Ishimura E, Kakehashi A, Mori K, Nishizawa Y, Inaba M, Wanibuchi H (2012). "Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis". Nephrol. Dial. Transplant. 27 (5): 1889–97. doi:10.1093/ndt/gfr682. PMID 22172726.