Neuron derived neurotrophic factor

Neuron derived neurotrophic factor (NDNF) is a secreted protein that, in humans, is located on chromosome 4. This protein helps in the growth, survival, migration, and differentiation of neurons. To assist with migration, NDNF shows neuro-repulsive effects on GnRH neurons. Loss of function (LoF) in the NDNF gene has been shown to be a cause of a disease known as congenital hypogonadotropic hypogonadism, which can have associated cleft lip and cleft palate. A preliminary study has shown that knock-down of ndnf reduces development of the ethmoid plate, which is homologous to the human palate.

3D protein structure of the NDNF gene as based on an Alphafold model.

NDNF
Identifiers
Aliases	NDNF, C4orf31, NORD, neuron-derived neurotrophic factor, neuron derived neurotrophic factor, HH25
External IDs	OMIM: 616506; MGI: 1915419; HomoloGene: 11593; GeneCards: NDNF; OMA:NDNF - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q27 Start 121,035,613 bp End 121,073,021 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C1 Start 65,648,574 bp End 65,689,310 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus visceral pleura lower lobe of lung periodontal fiber Epithelium of choroid plexus right lung bronchial epithelial cell tibia upper lobe of lung Top expressed in calvaria left lung lobe right lung right lung lobe renal corpuscle iris neural layer of retina otolith organ maxillary prominence utricle More reference expression data BioGPS n/a
Gene ontology Molecular function glycosaminoglycan binding heparin binding Cellular component extracellular matrix intracellular anatomical structure extracellular region Biological process negative regulation of neuron apoptotic process negative regulation of endothelial cell apoptotic process response to ischemia neuron migration cellular response to hypoxia angiogenesis nervous system development nitric oxide mediated signal transduction positive regulation of neuron projection development positive regulation of cell-substrate adhesion peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan extracellular matrix organization vascular wound healing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79625 68169 Ensembl ENSG00000173376 ENSMUSG00000049001 UniProt Q8TB73 Q8C119 RefSeq (mRNA) NM_024574 NM_172399 RefSeq (protein) NP_078850 NP_765987 Location (UCSC) Chr 4: 121.04 – 121.07 Mb Chr 6: 65.65 – 65.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Utine GE, Aktas D (2006). "Mosaicism for terminal deletion of 4q". Genetic Counseling. 17 (2): 205–209. PMID 16970039.
• Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, et al. (June 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Human Molecular Genetics. 19 (12): 2497–2506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–253. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.