Neuropeptide B

NPB
Identifiers
Aliases	NPB, L7, PPL7, PPneuropeptide B
External IDs	OMIM: 607996; MGI: 2387153; HomoloGene: 102151; GeneCards: NPB; OMA:NPB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,902,905 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,499,919 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; testicle; ; hypothalamus; ; substantia nigra; ; nucleus accumbens; ; amygdala; ; stromal cell of endometrium; ; Brodmann area 9; ; putamen; ; anterior cingulate cortex;
	Top expressed in
	stomach; ; embryo; ; testicle; ; morula; ; embryo; ; right kidney; ; spermatid; ; placenta; ; urinary bladder; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; G protein-coupled receptor binding;
Cellular component	extracellular region;
Biological process	neuropeptide signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	256933
	208990
	ENSG00000183979
	ENSMUSG00000044034
	Q8NG41
	Q8K4P1
	NM_148896
	NM_153288; NM_001347616; NM_001347617
	NP_683694
	NP_001334545; NP_001334546; NP_695020
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.^[5]^[6] It is expressed throughout the central nervous system with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183979 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044034 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
^ Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–56. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.