Neurotensin receptor 2

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.

NTSR2
Identifiers
Aliases	NTSR2, NTR2, Neurotensin receptor 2
External IDs	OMIM: 605538; MGI: 108018; HomoloGene: 7452; GeneCards: NTSR2; OMA:NTSR2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p25.1 Start 11,658,178 bp End 11,670,195 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 A1.1|12 7.98 cM Start 16,703,383 bp End 16,710,228 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus putamen amygdala substantia nigra hypothalamus testicle anterior cingulate cortex right frontal lobe external globus pallidus Top expressed in globus pallidus superior colliculus deep cerebellar nuclei central gray substance of midbrain dorsomedial hypothalamic nucleus dorsal tegmental nucleus medulla oblongata mammillary body inferior colliculi lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity G protein-coupled neurotensin receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process regulation of membrane potential phospholipase C-activating G protein-coupled receptor signaling pathway cell surface receptor signaling pathway neuropeptide signaling pathway sensory perception signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23620 18217 Ensembl ENSG00000169006 ENSMUSG00000020591 UniProt O95665 P70310 RefSeq (mRNA) NM_012344 NM_008747 NM_001361702 NM_001361703 RefSeq (protein) NP_036476 NP_032773 NP_001348631 NP_001348632 Location (UCSC) Chr 2: 11.66 – 11.67 Mb Chr 12: 16.7 – 16.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds Neurotensin (NT) as well as several other ligands already described for Neurotensin receptor 1. NT function is known to be a neuromodulator of dopamine and has hypothermic and analgesic properties in the brain and some peripheral organ function as well. NTS2 is found mostly in the brain through Northern-blot analysis.Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.

See also

• Neurotensin receptor

Further reading

• Vincent JP, Mazella J, Kitabgi P (July 1999). "Neurotensin and neurotensin receptors". Trends in Pharmacological Sciences. 20 (7): 302–309. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
• Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP (September 1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain". The Journal of Neuroscience. 16 (18): 5613–5620. doi:10.1523/jneurosci.16-18-05613.1996. PMC 6578974. PMID 8795617.
• Ramez M, Bagot M, Nikolova M, Boumsell L, Vita N, Chalon P, et al. (September 2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes". The Journal of Investigative Dermatology. 117 (3): 687–693. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.
• Martin S, Vincent JP, Mazella J (January 2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue". Journal of Cell Science. 115 (Pt 1): 165–173. doi:10.1242/jcs.115.1.165. PMID 11801734.
• Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, et al. (June 2002). "Expression of neurotensin receptors in human corneal keratocytes". Investigative Ophthalmology & Visual Science. 43 (6): 1765–1771. PMID 12036977.
• Leyton J, Garcia-Marin L, Jensen RT, Moody TW (May 2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells". European Journal of Pharmacology. 442 (3): 179–186. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.
• Somaï S, Gompel A, Rostène W, Forgez P (July 2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochemical and Biophysical Research Communications. 295 (2): 482–488. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.
• Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW (December 2004). "Common structural basis for constitutive activity of the ghrelin receptor family". The Journal of Biological Chemistry. 279 (51): 53806–53817. doi:10.1074/jbc.M407676200. PMID 15383539.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

• "Neurotensin Receptors: NTS₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.