The NiCo riboswitch is a riboswitch that senses nickel or cobalt ions.[1] Thus, it is an RNA molecule that specifically binds these metal ions, and regulates genes accordingly. The riboswitch is thought to be a part of a system that responds to toxic levels of these metal ions, although the riboswitch might also participate in dealing with the situation where insufficient levels of these trace elements are present in the cell.[1] The crystal structure of a NiCo riboswitch has been determined, and available evidence suggests that the riboswitches bind their metal-ion ligands cooperatively.[1]
| NiCo-AnGGAG | |
|---|---|
 Consensus secondary structure and sequence conservation of NiCo-AnGGAG riboswitch | |
| Identifiers | |
| Symbol | NiCo-AnGGAG |
| Rfam | RF03164 |
| Other data | |
| RNA type | Cis-reg |
| GO | GO:0046872 |
| SO | SO:0000035 |
| PDB structures | PDBe |
References
edit- ^ a b c Furukawa K, Ramesh A, Zhou Z, Weinberg Z, Vallery T, Winkler WC, Breaker RR (2015). "Bacterial riboswitches cooperatively bind Ni(2+) or Co(2+) ions and control expression of heavy metal transporters". Mol. Cell. 57 (6): 1088–1098. doi:10.1016/j.molcel.2015.02.009. PMC 4667775. PMID 25794617.