The Nickel/Cobalt Transporter (NicO) Family is a member of the Lysine Exporter (LysE) Superfamily.[1]
Homology
editHomologues of the NicO family have differing predicted topologies: 6, 7 and 8 TMSs. One such homologue, RcnA (YohM; TC# 2.A.113.1.1) of E. coli (274 aas) has 6 putative transmembrane segments (TMSs) in a 3 + 3 arrangement with a large hydrophilic loop between putativeTMSs 3 and 4.[2] Several homologues of RcnA (e.g., RcnA homologue from Ralstonia solanacearum; TC# 2.A.113.1.3; CAD17703) have 7 putative TMSs (4 + 3). Still another homologue, UreH of Methanocaldococcus janaschii (TC# 2.A.113.1.4) has 6 putative TMSs in a more characteristic 3 + 3 TMS arrangement. The NicO family within the LysE superfamily may have a common origin with the TOG superfamily, having lost TMSs 1 and 4 in the 8 TMS TOG superfamily topology.[3]
Function
editThis protein is believed to catalyze Co2+ and Ni2+ efflux.[2]
The overall reaction catalyzed by proteins of the NicO family is probably:
[Ni2+ or Co2+] (in) → [Ni2+ or Co2+] (out).
See also
edit- NiCoT family, family of nickel/cobalt transporters within the TOG superfamily
- Nickel
- Cobalt
- Transporter Classification Database
- Transport protein
Further reading
edit- Iwig, Jeffrey S.; Rowe, Jessica L.; Chivers, Peter T. (2006-10-01). "Nickel homeostasis in Escherichia coli – the rcnR-rcnA efflux pathway and its linkage to NikR function". Molecular Microbiology 62 (1): 252–262.doi:10.1111/j.1365-2958.2006.05369.x. ISSN 1365-2958.
- Marrero, Jeannette; Auling, Georg; Coto, Orquidea; Nies, Dietrich H. (2007-01-01). "High-level resistance to cobalt and nickel but probably no transenvelope efflux: Metal resistance in the Cuban Serratia marcescens strain C-1". Microbial Ecology 53 (1): 123–133. doi:10.1007/s00248-006-9152-7. ISSN 0095-3628. PMID 17186148.
- Protchenko, Olga; Rodriguez-Suarez, Roberto; Androphy, Rachel; Bussey, Howard; Philpott, Caroline C. (2006-07-28). "A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum". The Journal of Biological Chemistry 281 (30): 21445–21457.doi:10.1074/jbc.M512812200. ISSN 0021-9258.PMID 16717099.
References
edit- ^ Tsu, Brian V.; Saier, Milton H. (2015-01-01). "The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PLOS ONE. 10 (10): e0137184. Bibcode:2015PLoSO..1037184T. doi:10.1371/journal.pone.0137184. ISSN 1932-6203. PMC 4608589. PMID 26474485.
- ^ a b Rodrigue, Agnès; Effantin, Géraldine; Mandrand-Berthelot, Marie-Andrée (2005-04-15). "Identification of rcnA (yohM), a Nickel and Cobalt Resistance Gene in Escherichia coli". Journal of Bacteriology. 187 (8): 2912–2916. doi:10.1128/JB.187.8.2912-2916.2005. ISSN 0021-9193. PMC 1070376. PMID 15805538.
- ^ "The Nickel/cobalt Transporter (NicO) Family". Transporter Classification Database. Retrieved 2016-02-29.
External links
edit- The Nickel/Cobalt Transporter Family Transporter Classification Database
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