Nicotinate riboside kinase (EC 2.7.1.173, ribosylnicotinic acid kinase, nicotinic acid riboside kinase, NRK1) is an enzyme with systematic name ATP:beta-D-ribosylnicotinate 5-phosphotransferase.[1] This enzyme catalyses the following chemical reaction
| Nicotinate riboside kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.173 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ATP + beta-D-ribosylnicotinate ADP + nicotinate beta-D-ribonucleotide
The enzyme from yeast and human also acts as EC 2.7.1.22 (ribosylnicotinamide kinase).
References
edit- ^ Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C (October 2007). "Nicotinamide riboside kinase structures reveal new pathways to NAD+". PLOS Biology. 5 (10): e263. doi:10.1371/journal.pbio.0050263. PMC 1994991. PMID 17914902.
External links
edit- Nicotinate+riboside+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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