Nierstein-Oppenheim is a former Verbandsgemeinde ("collective municipality") in the district Mainz-Bingen (Rheinhessen) in Rhineland-Palatinate, Germany. It is situated on the left bank of the Rhine, approx. 15 km south-east of Mainz. On 1 July 2014 it merged into the new Verbandsgemeinde Rhein-Selz.

The Verbandsgemeinde consisted of the following eleven Ortsgemeinden ("local municipalities"):

  1. Dalheim
  2. Dexheim
  3. Dienheim
  4. Friesenheim
  5. Hahnheim
  6. Köngernheim
  7. Mommenheim
  8. Nierstein
  9. Oppenheim
  10. Selzen
  11. Undenheim
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49°51′N 8°22′E / 49.850°N 8.367°E / 49.850; 8.367