Nkx2-2as (Nkx2-2 antisense) is a long non-coding RNA. It is located in the cytoplasm of the cell. Nkx2-2as is involved in Neural development. Overexpression of Nkx2-2as results in increased levels of expression of the homeobox gene Nkx2-2 and enhances induction of the differentiation of oligodendrocytes.[1][2][3][4] Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes.[1][2]
| NK2 transcription factor related, locus 2 (Drosophila), antisense | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | Nkx2-2as |
| Entrez | 100313531 |
| RefSeq (mRNA) | NR_030769 |
| Other data | |
| Chromosome | 2: 146.99 - 147.18 Mb |
See also
editReferences
edit- ^ a b Tochitani S, Hayashizaki Y (August 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications. 372 (4): 691–6. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132.
- ^ a b Szymański M, Barciszewski J (2009). "Noncoding RNAs in the Development, Function and Pathologies of the Central Nervous System". In Erdmann VA, Reifenberger G, Barciszewski J (eds.). Therapeutic Ribonucleic Acids in Brain Tumors. Berlin, Heidelberg: Springer. pp. 453–470. doi:10.1007/978-3-642-00475-9_20. ISBN 978-3-642-00474-2.
- ^ Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF (February 2010). "Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation". BMC Neuroscience. 11: 14. doi:10.1186/1471-2202-11-14. PMC 2829031. PMID 20137068.
- ^ Qureshi IA, Mattick JS, Mehler MF (June 2010). "Long non-coding RNAs in nervous system function and disease". Brain Research. 1338: 20–35. doi:10.1016/j.brainres.2010.03.110. PMC 2883659. PMID 20380817.
Further reading
edit- Mattick JS (April 2009). "The genetic signatures of noncoding RNAs". PLOS Genetics. 5 (4): e1000459. doi:10.1371/journal.pgen.1000459. PMC 2667263. PMID 19390609.