Non-specific polyamine oxidase (EC 1.5.3.17, polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming).[1][2][3] This enzyme catalyses the following chemical reaction
| Non-specific polyamine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.3.17 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (1) spermine + O2 + H2O spermidine + 3-aminopropanal + H2O2
- (2) spermidine + O2 + H2O putrescine + 3-aminopropanal + H2O2
- (3) N1-acetylspermine + O2 + H2O spermidine + 3-acetamidopropanal + H2O2
- (4) N1-acetylspermidine + O2 + H2O putrescine + 3-acetamidopropanal + H2O2
This enzyme is flavoprotein (FAD).
References
edit- ^ Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA (August 2008). "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis". Plant Physiology. 147 (4): 1845–57. doi:10.1104/pp.108.123802. PMC 2492618. PMID 18583528.
- ^ Müller S, Walter RD (April 1992). "Purification and characterization of polyamine oxidase from Ascaris suum". The Biochemical Journal. 283 ( Pt 1): 75–80. PMC 1130995. PMID 1567380.
- ^ Landry J, Sternglanz R (April 2003). "Yeast Fms1 is a FAD-utilizing polyamine oxidase". Biochemical and Biophysical Research Communications. 303 (3): 771–6. doi:10.1016/s0006-291x(03)00416-9. PMID 12670477.
External links
edit- Non-specific+polyamine+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
