This is a list of notable alumni of the Sigma Chi Fraternity. Many notable Sigma Chi Brothers are awarded the Significant Sig Award by headquarters, indicated by as superscriptS.
Former men's Basketball Coach, Villanova University, 6-time Big East Coach of the Year and 2-time Naismith National Coach of the year, reached four Final Fours (2009, 2016, 2018, 2022) and won two national championships in 2016 and 2018 with Villanova.
Won the 1993 Nobel Prize in Chemistry for his development of the Polymerase chain reaction (PCR), a central technique in biochemistry and molecular biology which allows the amplification of specified DNA sequences
Cardiothoracic Surgeon, performed the first open heart surgery west of the Mississippi, current President of the Church of Jesus Christ of Latter Day Saints
Only person in history to serve as Chief of Staff for Governor of Florida (2011–12), President of Florida Senate (2011) and Speaker of Florida House of Representatives (1998–2000)
Canadian Ambassador to Austria, the International Atomic Energy Agency, United Nations Industrial Development Organization, the United Nations in Geneva and General Agreement on Tariffs and Trade.
Deputy Director, National Geospatial-Intelligence Agency; Presidential Rank of Distinguished Executive; Retired Col, USAF; Awards include the Distinguished Flying Cross for combat operations, Presidential Meritorious Rank, the Legion of Merit
Conservative political columnist, writer, author and professor at University of North Carolina, Wilmington (Author of Welcome to the Ivory Tower of Babel: Confessions of a Conservative College Professor,Feminists Say the Darndest Things: a Politically Incorrect Professor Confronts 'Womyn' on Campus,Letters to a Young Progressive: How to Avoid Wasting Your Time Protesting Things You Don't Understand).
^Underwood, Thomas A. (2000). Allen Tate: Orphan of the South. Princeton, New Jersey: Princeton University Press. p. 41. ISBN9780691069500. OCLC44090472. Across the street, in the Sigma Chi fraternity, he found a distracted seventeen-year-old named Merrill Moore, who was well on the way to becoming the most prolific sonneteer in history.
^"The Shield Yearbook". Murray State University Yearbooks. Murray State University: 35. 1960. Retrieved December 9, 2021.