Nuclear mitotic apparatus protein 1

Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.

NUMA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RO2
Identifiers
Aliases	NUMA1, NUMA, NMP-22, nuclear mitotic apparatus protein 1
External IDs	OMIM: 164009; MGI: 2443665; HomoloGene: 38150; GeneCards: NUMA1; OMA:NUMA1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.4 Start 72,002,864 bp End 72,080,693 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E2 Start 101,583,318 bp End 101,664,171 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of uterus canal of the cervix left ovary right ovary gastric mucosa muscle layer of sigmoid colon ectocervix right lobe of thyroid gland ventricular zone Top expressed in genital tubercle Rostral migratory stream ventricular zone vas deferens neural layer of retina cumulus cell efferent ductule Gonadal ridge thymus internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity protein binding microtubule binding protein C-terminus binding tubulin binding phosphatidylinositol binding microtubule plus-end binding microtubule minus-end binding dynein complex binding disordered domain specific binding lipid binding protein domain specific binding protein-containing complex binding Cellular component extracellular exosome spindle mitotic spindle chromosome microtubule organizing center Golgi membrane apical part of cell mitotic spindle astral microtubule centrosome microtubule soma dendrite cytoskeleton spindle microtubule spindle pole nucleus cytoplasm cytosol nuclear matrix extrinsic component of plasma membrane spindle pole centrosome microtubule plus-end microtubule minus-end cortical microtubule microtubule bundle mitotic spindle pole cell cortex region cytoplasmic microtubule bundle mitotic spindle midzone nucleoplasm plasma membrane cell cortex membrane lateral cell cortex lateral plasma membrane protein-containing complex Biological process lung epithelial cell differentiation cell cycle cell division meiosis nucleus organization establishment of mitotic spindle orientation microtubule bundle formation positive regulation of BMP signaling pathway astral microtubule organization positive regulation of microtubule polymerization positive regulation of intracellular transport positive regulation of keratinocyte differentiation positive regulation of hair follicle development positive regulation of chromosome segregation anastral spindle assembly regulation of mitotic spindle organization regulation of metaphase plate congression positive regulation of protein localization to spindle pole body positive regulation of mitotic spindle elongation positive regulation of protein localization to cell cortex positive regulation of chromosome separation positive regulation of spindle assembly chromosome segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4926 101706 Ensembl ENSG00000137497 ENSMUSG00000066306 UniProt Q14980 Q3SYK8 E9Q7G0 RefSeq (mRNA) NM_001286561 NM_006185 NM_133947 RefSeq (protein) NP_001273490 NP_006176 NP_006176.2 NP_598708 NP_001390473 NP_001390474 NP_001390475 NP_001390476 NP_001390477 NP_001390478 NP_001390479 NP_001390480 NP_001390481 NP_001390482 Location (UCSC) Chr 11: 72 – 72.08 Mb Chr 7: 101.58 – 101.66 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1, Band 4.1, GPSM2 and EPB41L1.

Further reading

• Sun QY, Schatten H (2006). "Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein". Front. Biosci. 11: 1137–46. doi:10.2741/1868. PMID 16146802.
• Yang CH, Lambie EJ, Snyder M (1992). "NuMA: an unusually long coiled-coil related protein in the mammalian nucleus". J. Cell Biol. 116 (6): 1303–1317. doi:10.1083/jcb.116.6.1303. PMC 2289379. PMID 1541630.
• Compton DA, Szilak I, Cleveland DW (1992). "Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis". J. Cell Biol. 116 (6): 1395–1408. doi:10.1083/jcb.116.6.1395. PMC 2289377. PMID 1541636.
• Lydersen BK, Pettijohn DE (1981). "Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell". Cell. 22 (2 Pt 2): 489–499. doi:10.1016/0092-8674(80)90359-1. PMID 7004645. S2CID 27884304.
• Maekawa T, Kuriyama R (1993). "Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic MAP located at the spindle pole and characterized as a homologous protein to NuMA". J. Cell Sci. 105 (2): 589–600. doi:10.1242/jcs.105.2.589. PMID 8408288.
• Tang TK, Tang CJ, Chen YL, Wu CW (1993). "Nuclear proteins of the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1". J. Cell Sci. 104 (2): 249–60. doi:10.1242/jcs.104.2.249. PMID 8505359.
• Wells RA, Catzavelos C, Kamel-Reid S (1997). "Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia". Nat. Genet. 17 (1): 109–113. doi:10.1038/ng0997-109. PMID 9288109. S2CID 21975861.
• Andrade F, Roy S, Nicholson D, Thornberry N, Rosen A, Casciola-Rosen L (1998). "Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis". Immunity. 8 (4): 451–460. doi:10.1016/S1074-7613(00)80550-6. PMID 9586635.
• Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity. 10 (1): 127–136. doi:10.1016/S1074-7613(00)80013-8. PMID 10023777.
• Mattagajasingh SN, Huang SC, Hartenstein JS, Snyder M, Marchesi VT, Benz EJ (1999). "A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein". J. Cell Biol. 145 (1): 29–43. doi:10.1083/jcb.145.1.29. PMC 2148212. PMID 10189366.
• Clark IB, Meyer DI (2000). "Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase". J. Cell Sci. 112 (20): 3507–18. doi:10.1242/jcs.112.20.3507. PMID 10504299.
• Ye K, Compton DA, Lai MM, Walensky LD, Snyder SH (2000). "Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor". J. Neurosci. 19 (24): 10747–56. doi:10.1523/JNEUROSCI.19-24-10747.1999. PMC 6784956. PMID 10594058.
• Taimen P, Viljamaa M, Kallajoki M (2000). "Preferential expression of NuMA in the nuclei of proliferating cells". Exp. Cell Res. 256 (1): 140–149. doi:10.1006/excr.2000.4799. PMID 10739661.
• Harborth J, Weber K, Osborn M (2000). "GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA". J. Biol. Chem. 275 (41): 31979–31985. doi:10.1074/jbc.M000994200. hdl:11858/00-001M-0000-0012-F868-B. PMID 10913114.
• Gregson HC, Schmiesing JA, Kim JS, Kobayashi T, Zhou S, Yokomori K (2002). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50): 47575–47582. doi:10.1074/jbc.M103364200. PMID 11590136.
• Du Q, Stukenberg PT, Macara IG (2002). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–1075. doi:10.1038/ncb1201-1069. PMID 11781568. S2CID 7955950.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Haren L, Merdes A (2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules". J. Cell Sci. 115 (Pt 9): 1815–24. doi:10.1242/jcs.115.9.1815. PMID 11956313.
• Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–31892. doi:10.1074/jbc.M203916200. PMID 12080061.

External links

• Overview of all the structural information available in the PDB for UniProt: Q14980 (Nuclear mitotic apparatus protein 1) at the PDBe-KB.