O'Keefe/O'Keeffe is an Irish surname, from the (Irish:O'Caoimh/Caomh), meaning 'tender, beautiful, gentle, kind, handsome'. It has links to Irish Royalty, with the family descended from Art Caemh who was the son of Finguine.

O'Keefe/O'Keeffe is related to a number of Irish surnames, the first being "O'Caomhain" meaning "son of Kevin", more commonly anglicized as Kavanagh, Keaveney, and MacKinnon, derived from "fionn" = "fair". The other connection are Kennan and Gannon, both deriving from "fionn" = "white".

People with this surname include:

See also

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