O-774

O-774
Identifiers
	IUPAC name 7-[(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-3-yl]-7-methyloctanenitrile;
CAS Number	336104-74-6 [UNII];
PubChem CID	10833730;
ChemSpider	9009030;
UNII	77GNH26GH3;
ChEMBL	ChEMBL138917;
Chemical and physical data
Formula	C25H35NO2
Molar mass	381.560 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#CCCCCCC(c2cc1OC([C@@H]3C/C=C(\C[C@H]3c1c(O)c2)C)(C)C)(C)C;
	InChI InChI=1S/C25H35NO2/c1-17-10-11-20-19(14-17)23-21(27)15-18(16-22(23)28-25(20,4)5)24(2,3)12-8-6-7-9-13-26/h10,15-16,19-20,27H,6-9,11-12,14H2,1-5H3/t19-,20-/m1/s1; Key:RVTLXKSJDYALPU-WOJBJXKFSA-N;
	(what is this?)

O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, with a K_i of 0.6 nM at CB₁, and very potent cannabinoid effects in animal studies.^[1]^[2]

References

^ Singer M, Ryan WJ, Saha B, Martin BR, Razdan RK (October 1998). "Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol". Journal of Medicinal Chemistry. 41 (22): 4400–7. doi:10.1021/jm9803875. PMID 9784115.
^ Reggio PH, ed. (2009). "Cannabinoid Receptor Ligands and Structure-Activity Relationships.". The Cannabinoid Receptors. Part I. Humana Press. pp. 6–9. ISBN 978-1-58829-712-9.

This cannabinoid related article is a stub. You can help Wikipedia by expanding it.

[pmid9784115-1] Singer M, Ryan WJ, Saha B, Martin BR, Razdan RK (October 1998). "Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol". Journal of Medicinal Chemistry. 41 (22): 4400–7. doi:10.1021/jm9803875. PMID 9784115.

[2] Reggio PH, ed. (2009). "Cannabinoid Receptor Ligands and Structure-Activity Relationships.". The Cannabinoid Receptors. Part I. Humana Press. pp. 6–9. ISBN 978-1-58829-712-9.

[1]

[2]

Identifiers

IUPAC name 7-[(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-3-yl]-7-methyloctanenitrile
CAS Number	336104-74-6^N[UNII]
PubChem CID	10833730
ChemSpider	9009030
UNII	77GNH26GH3
ChEMBL	ChEMBL138917
Chemical and physical data
Formula	C₂₅H₃₅NO₂
Molar mass	381.560 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N#CCCCCCC(c2cc1OC([C@@H]3C/C=C(\C[C@H]3c1c(O)c2)C)(C)C)(C)C
InChI InChI=1S/C25H35NO2/c1-17-10-11-20-19(14-17)23-21(27)15-18(16-22(23)28-25(20,4)5)24(2,3)12-8-6-7-9-13-26/h10,15-16,19-20,27H,6-9,11-12,14H2,1-5H3/t19-,20-/m1/s1 Key:RVTLXKSJDYALPU-WOJBJXKFSA-N
^NY (what is this?)

O-774

See also

References