o-Aminophenol oxidase (EC 1.10.3.4, isophenoxazine synthase, o-aminophenol:O2 oxidoreductase, 2-aminophenol:O2 oxidoreductase, GriF) is an enzyme with systematic name 2-aminophenol:oxygen oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| o-Aminophenol oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.10.3.4 | ||||||||
| CAS no. | 9013-85-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2 o-aminophenol + O2 + acceptor ⇌ 2-aminophenoxazin-3-one + reduced acceptor + 2 H2O (overall reaction)
- (1a) 2 2-aminophenol + O2 ⇌ 2 6-iminocyclohexa-2,4-dienone + 2 H2O
- (1b) 2 6-iminocyclohexa-2,4-dienone + acceptor ⇌ 2-aminophenoxazin-3-one + reduced acceptor (spontaneous)
o-Aminophenol oxidase is a flavoprotein.
References
edit- ^ Nair PM, Vaidyanathan CS (March 1964). "Isophenoxazine synthase". Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects. 81 (3): 507–16. doi:10.1016/0926-6569(64)90135-x. PMID 14170322.
- ^ Nair PM, Vining LC (February 1965). "Isophenoxazine synthase apoenzyme from Pycnoporus coccineus". Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation. 96 (2): 318–27. doi:10.1016/0926-6593(65)90015-9. PMID 14298835.
- ^ Subba Rao PV, Vaidyanathan CS (February 1967). "Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra". Archives of Biochemistry and Biophysics. 118 (2): 388–94. doi:10.1016/0003-9861(67)90365-7. PMID 4166439.
- ^ Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S (January 2006). "A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone". The Journal of Biological Chemistry. 281 (2): 824–33. doi:10.1074/jbc.M505806200. PMID 16282322.
External links
edit- O-aminophenol+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
