O-phospho-L-seryl-tRNA:Cys-tRNA synthase

O-phospho-L-seryl-tRNA:Cys-tRNA synthase
O-phospho-L-seryl-tRNA:Cys-tRNA synthase
Identifiers
EC no.	2.5.1.73
CAS no.	1239229-21-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

O-phospho-L-seryl-tRNA:Cys-tRNA synthase (EC 2.5.1.73, SepCysS, Sep-tRNA:Cys-tRNA synthase) is an enzyme with systematic name O-phospho-L-seryl-tRNACys:hydrogen sulfide 2-aminopropanoate transferase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

O-phospho-L-seryl-tRNACys + sulfide

\rightleftharpoons

L-cysteinyl-tRNACys + phosphate

References

^ Fukunaga R, Yokoyama S (June 2007). "Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus". Journal of Molecular Biology. 370 (1): 128–41. doi:10.1016/j.jmb.2007.04.050. PMID 17512006.
^ Hauenstein SI, Perona JJ (August 2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". The Journal of Biological Chemistry. 283 (32): 22007–17. doi:10.1074/jbc.M801839200. PMC 2494925. PMID 18559341.
^ Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (December 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proceedings of the National Academy of Sciences of the United States of America. 103 (50): 18923–7. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.