Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene.[5][6][7]

OAZ2
Identifiers
AliasesOAZ2, AZ2, ornithine decarboxylase antizyme 2
External IDsOMIM: 604152; MGI: 109492; HomoloGene: 31094; GeneCards: OAZ2; OMA:OAZ2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002537
NM_001301302

NM_001301307
NM_010952

RefSeq (protein)

NP_001288231
NP_002528

NP_001288236
NP_035082

Location (UCSC)Chr 15: 64.69 – 64.7 MbChr 9: 65.58 – 65.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180304Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040652Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ivanov IP, Gesteland RF, Atkins JF (Dec 1998). "A second mammalian antizyme: conservation of programmed ribosomal frameshifting". Genomics. 52 (2): 119–29. doi:10.1006/geno.1998.5434. PMID 9782076.
  6. ^ Zhou J, Atkins JF, Gesteland RF (Jul 1999). "Structure of human ornithine decarboxylase antizyme 2 gene". Gene. 232 (2): 165–71. doi:10.1016/S0378-1119(99)00128-6. PMID 10352227.
  7. ^ a b "Entrez Gene: OAZ2 ornithine decarboxylase antizyme 2".

Further reading

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