Outer dense fiber protein 1 is a protein that in humans is encoded by the ODF1 gene .[ 5] [ 6]
ODF1 Identifiers Aliases ODF1 External IDs OMIM : 182878 ; MGI : 97424 ; HomoloGene : 7456 ; GeneCards : ODF1 ; OMA :ODF1 - orthologs Wikidata
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation . Defects in the outer dense fibers lead to abnormal sperm morphology and infertility . The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000155087 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061923 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Gastmann O, Burfeind P, Gunther E, Hameister H, Szpirer C, Hoyer-Fender S (Mar 1994). "Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene". Mol Reprod Dev . 36 (4): 407–418. doi :10.1002/mrd.1080360402 . PMID 8305202 . S2CID 2447785 . ^ a b "Entrez Gene: ODF1 outer dense fiber of sperm tails 1" .
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