Olfactory receptor 51B2 is a protein that in humans is encoded by the OR51B2 gene .[ 5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[ 5]
As of 2015, OR51B2 was an orphan receptor , meaning that no odorants have been identified which bind to it.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000279012 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063615 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: OR51B2 olfactory receptor, family 51, subfamily B, member 2" .^ de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal . 30 (5): 342–361. doi :10.1002/ffj.3249 .
Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH (April 1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes" . Proceedings of the National Academy of Sciences of the United States of America . 96 (9): 5129–34. Bibcode :1999PNAS...96.5129B . doi :10.1073/pnas.96.9.5129 PMC 21828 PMID 10220430 . Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R (December 2000). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters" . Proceedings of the National Academy of Sciences of the United States of America . 97 (26): 14560–5. Bibcode :2000PNAS...9714560B . doi :10.1073/pnas.97.26.14560 PMC 18958 PMID 11121057 . Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics . 80 (3): 295–302. doi :10.1006/geno.2002.6830 . PMID 12213199 .
