OR52A1

Olfactory receptor 52A1 is a protein that in humans is encoded by the OR52A1 gene.

OR52A1
Identifiers
Aliases	OR52A1, HPFH1OR, olfactory receptor family 52 subfamily A member 1
External IDs	MGI: 1341790; HomoloGene: 130658; GeneCards: OR52A1; OMA:OR52A1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 5,146,824 bp End 5,154,757 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E3 Start 103,423,565 bp End 103,428,905 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle skin of thigh Top expressed in supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23538 18369 Ensembl ENSG00000182070 ENSMUSG00000061626 UniProt Q9UKL2 E9PYY2 RefSeq (mRNA) NM_012375 NM_013620 RefSeq (protein) NP_036507 NP_038648 Location (UCSC) Chr 11: 5.15 – 5.15 Mb Chr 7: 103.42 – 103.43 Mb PubMed search
Wikidata
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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR52A1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.