ORAI2

ORAI2
Identifiers
Aliases	ORAI2, C7orf19, CBCIP2, MEM142B, TMEM142B, ORAI calcium release-activated calcium modulator 2
External IDs	OMIM: 610929; MGI: 2443195; HomoloGene: 32799; GeneCards: ORAI2; OMA:ORAI2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	102,456,825 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	136,199,567 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; ventral tegmental area; ; pylorus; ; superior vestibular nucleus; ; nipple; ; inferior ganglion of vagus nerve; ; superior surface of tongue; ; trigeminal ganglion; ; pericardium; ; subthalamic nucleus;
	Top expressed in
	granulocyte; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; primary visual cortex; ; superior frontal gyrus; ; piriform cortex; ; thymus; ; olfactory tubercle; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	store-operated calcium channel activity; protein binding;
Cellular component	growth cone; integral component of membrane; membrane;
Biological process	store-operated calcium entry; calcium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	80228
	269717
	ENSG00000160991
	ENSMUSG00000039747
	Q96SN7
	Q8BH10
	NM_032831; NM_001126340; NM_001271818; NM_001271819
	NM_178751
	NP_001119812; NP_001258747; NP_001258748; NP_116220
	NP_848866
	Wikidata
View/Edit Human	View/Edit Mouse

Protein orai-2 is a protein that in humans is encoded by the ORAI2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160991 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039747 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature. 441 (7090): 179–85. Bibcode:2006Natur.441..179F. doi:10.1038/nature04702. PMID 16582901. S2CID 1605392.
^ "Entrez Gene: TMEM142B transmembrane protein 142B".

DeHaven WI, Smyth JT, Boyles RR, Putney JW (2007). "Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels". J. Biol. Chem. 282 (24): 17548–56. doi:10.1074/jbc.M611374200. PMID 17452328.
Mercer JC, Dehaven WI, Smyth JT, et al. (2006). "Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1". J. Biol. Chem. 281 (34): 24979–90. doi:10.1074/jbc.M604589200. PMC 1633822. PMID 16807233.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160991 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039747 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16582901-5] Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature. 441 (7090): 179–85. Bibcode:2006Natur.441..179F. doi:10.1038/nature04702. PMID 16582901. S2CID 1605392.

[entrez-6] "Entrez Gene: TMEM142B transmembrane protein 142B".

[5]

[6]

[1]

[2]

[3]

[4]

ORAI2

References

Further reading