OSM-9 also known as OSMotic avoidance abnormal family member 9 is a protein which in the nematode worm C. elegans is encoded by the osm-9 gene.[1]
| OSMotic avoidance abnormal family member (osm-9) (Caenorhabditis elegans) | |
|---|---|
| Identifiers | |
| Symbol | OSM-9 |
| NCBI gene | 177117 |
Function
editThe OSM-9 protein is required for some olfactory and osmotic stimuli as well as a mechanosensory response to nose touch. This protein encodes a protein with ankyrin repeats and is closely related in sequence to the mammalian TRPV ion channels.[1] OSM-9 controls the biosynthesis of serotonin via regulation of the expression of the enzyme tryptophan hydroxylase.[2]
References
edit- ^ a b Colbert HA, Smith TL, Bargmann CI (November 1997). "OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans". J. Neurosci. 17 (21): 8259–69. doi:10.1523/JNEUROSCI.17-21-08259.1997. PMC 6573730. PMID 9334401.
- ^ Zhang S, Sokolchik I, Blanco G, Sze JY (April 2004). "Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons". Development. 131 (7): 1629–38. doi:10.1242/dev.01047. PMID 14998926.
Further reading
edit- Kahn-Kirby AH, Bargmann CI (2006). "TRP channels in C. elegans". Annu. Rev. Physiol. 68 (1): 719–36. doi:10.1146/annurev.physiol.68.040204.100715. PMID 16460289.
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