Ohyun Kwon is an American chemist who is a professor at the University of California, Los Angeles. Her research considers new methodologies for organic transformations and the development of chiral catalysts.
Ohyun Kwon | |
|---|---|
| Alma mater | Seoul National University Columbia University |
| Scientific career | |
| Institutions | University of California, Los Angeles Harvard University |
| Thesis | Studies in syntheses of the natural products (1998) |
| Doctoral advisor | Samuel J. Danishefsky |
Early life and education
editKwon was born in South Korea. She attended the Seoul National University, where she majored in chemistry.[1] She moved to the United States for graduate studies, first joining Columbia University to work in the research group of Samuel J. Danishefsky.[2][3] Her doctorate considered the synthesis of glycolipid Ganglio-N-tetraosylceramide (asialo GM1).[2] Afterwards, Kwon moved to Harvard University as a postdoctoral fellow in the laboratory of Stuart Schreiber,[4] where she worked on a diversity oriented synthesis of macrocycles and multi-cyclic compounds.[2]
Research and career
editKwon was appointed to the faculty at the University of California, Los Angeles (UCLA) in 2001. Her research considers the development of chiral catalysts, target-oriented synthesis of natural compounds and diversity oriented synthesis of natural-product like molecules.[2] She has explored the activation of the C(sp3)–C(sp2) bond of alkenes that is common in natural products.[2] These can be used for the generation of biologically relevant molecules and total synthesis. Kwon developed organic, phosphine-based catalysts for chemical reactions. She has shown that phosphine-catalysed alleviate annulations can be used to create natural products of medical significance.[2]
Kwon showed that chiral phosphines can be used for asymmetric catalysis, including DIPAMP, DIOP and BINAP.[2][5] These phosphines include stereogenic phosphorus centres, axial chirality and stereogenic carbon centres. Kwon developed a family of phosphines with stereogenic carbon and phosphorus centres that are available from Sigma-Aldrich.[6][7]
Awards and honors
edit- 2018 University of California Center for Accelerated Innovation Technology Development Grant[8]
- 2019 Novartis Chemistry Lectureship Award[9]
- 2019 Herbert Newby McCoy Award[10]
Selected publications
edit- Hongchao Guo; Yi Chiao Fan; Zhanhu Sun; Yang Wu; Ohyun Kwon (27 September 2018). "Phosphine Organocatalysis". Chemical Reviews. 118 (20): 10049–10293. doi:10.1021/ACS.CHEMREV.8B00081. ISSN 0009-2665. PMC 6218176. PMID 30260217. Wikidata Q57790695.
- Xue-Feng Zhu; Jie Lan; Ohyun Kwon (1 April 2003). "An expedient phosphine-catalyzed [4 + 2] annulation: synthesis of highly functionalized tetrahydropyridines". Journal of the American Chemical Society. 125 (16): 4716–4717. doi:10.1021/JA0344009. ISSN 0002-7863. PMID 12696883. Wikidata Q44404323.
- Zhiming Wang; Xingzhu Xu; Ohyun Kwon (24 March 2014). "Phosphine catalysis of allenes with electrophiles". Chemical Society Reviews. 43 (9): 2927–2940. doi:10.1039/C4CS00054D. ISSN 0306-0012. PMC 4059616. PMID 24663290. Wikidata Q38198956.
References
edit- ^ Ohyun Kwon. OCLC 4780088793.
- ^ a b c d e f g "Kwon, Ohyun | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
- ^ "Directory | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
- ^ Wood, John L. (2020-04-14). Organic Syntheses. John Wiley & Sons. ISBN 978-1-119-70776-9.
- ^ Kwon, Ohyun. "Phosphine-Catalyzed Annulations and Their Applications".
{{cite journal}}: Cite journal requires|journal=(help) - ^ "Kwon Phosphines: P-Chiral Monodentate Phosphines from Hydroxyproline". Sigma-Aldrich. Retrieved 2021-06-02.
- ^ "Kwon Chiral Phosphines - Chiral Catalysts, Ligands, and Reagents". Sigma-Aldrich. Retrieved 2021-06-02.
- ^ "UC CAI Technology Development Award | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
- ^ "Kwon group's discovery of new chemical reaction published in Science | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
- ^ "2019-2020 Herbert Newby McCoy Award | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.