omega-Atracotoxin (ω-atracotoxin) is an insect-specific neurotoxin produced by the Blue Mountains funnel-web spider. Its phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.[1]
| ω-Atracotoxin | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | Omega-toxin | ||||||||||
| Pfam | PF06357 | ||||||||||
| InterPro | IPR009415 | ||||||||||
| SCOP2 | 1hvw / SCOPe / SUPFAM | ||||||||||
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See also
editReferences
edit- ^ King GF, Fletcher JI, Tedford HW (2001). "Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a". J. Biol. Chem. 276 (28): 26568–26576. doi:10.1074/jbc.M102199200. PMID 11313356.
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