Opie may refer to:
- Opie (name), a list of people and fictional characters with the given name, nickname, or surname
- Acronyms OPIE:
- OPIE (Entomology) (Office pour l'Information Eco-entomologique), a French government organisation devoted to entomology
- OPIE Authentication System, a one-time password authentication system for Unix based on S/KEY
See also
edit- Okey
- Okie
- opy, ISO 639-3 code for the Ofayé language of Brazil