Oppau may refer to:
- Ludwigshafen-Oppau, a suburb of Ludwigshafen, Germany
- Oppau explosion, which occurred there in 1921
- Opawa, Lower Silesian Voivodeship (German: Oppau), Poland
- Zábřeh, Dolní Benešov, Czech Republic; See List of historical German and Czech names for places in the Czech Republic