Otacílio is a Portuguese given name (sometimes surname), may refer to:
- Otacílio Mariano Neto (born 1982), Brazilian footballer
- Otacílio Gonçalves da Silva Junior, Brazilian football manager
- Otacílio Jales da Silva (born 1984), Brazilian footballer
- Cilinho, real name Otacílio Pires de Camargo, Brazilian football manager