Otterson may refer to:
- Billy Otterson (1862–1940), baseball player
- Jack Otterson (1905–1991), art director
- Joel Otterson (born 1959), artist
- John E. Otterson (1881–1964), American engineer and business executive
- Michael Otterson, managing director of Public Affairs for The Church of Jesus Christ of Latter-day Saints
- Ryan Otterson (born 1986), football offensive tackle