P2RY13

P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene.

P2RY13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6U
Identifiers
Aliases	P2RY13, GPCR1, GPR86, GPR94, P2Y13, SP174, FKSG77, purinergic receptor P2Y13
External IDs	OMIM: 606380; MGI: 1921441; HomoloGene: 12543; GeneCards: P2RY13; OMA:P2RY13 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q25.1 Start 151,326,312 bp End 151,329,549 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 D Start 59,115,313 bp End 59,118,303 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte spleen bone marrow trabecular bone bone marrow cells appendix lymph node testicle Top expressed in granulocyte mesenteric lymph nodes spleen lumbar subsegment of spinal cord Region I of hippocampus proper dentate gyrus of hippocampal formation granule cell embryo bone marrow visual cortex stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane endoplasmic reticulum membrane Biological process cellular response to organic cyclic compound negative regulation of adenylate cyclase activity signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway G protein-coupled receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53829 74191 Ensembl ENSG00000181631 ENSMUSG00000036362 UniProt Q9BPV8 Q9D8I2 RefSeq (mRNA) NM_023914 NM_176894 NM_028808 RefSeq (protein) NP_795713 NP_083084 Location (UCSC) Chr 3: 151.33 – 151.33 Mb Chr 3: 59.12 – 59.12 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene, P2Y₁₃, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene.

See also

• P2Y receptor

Further reading

• Communi D, Gonzalez NS, Detheux M, et al. (2001). "Identification of a novel human ADP receptor coupled to G(i)". J. Biol. Chem. 276 (44): 41479–85. doi:10.1074/jbc.M105912200. PMID 11546776.
• Zhang FL, Luo L, Gustafson E, et al. (2002). "P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse". J. Pharmacol. Exp. Ther. 301 (2): 705–13. doi:10.1124/jpet.301.2.705. PMID 11961076.
• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fabre AC, Malaval C, Ben Addi A, et al. (2010). "P2Y13 receptor is critical for reverse cholesterol transport". Hepatology. 52 (4): 1477–83. doi:10.1002/hep.23897. PMID 20830789. S2CID 5833128.

External links

• "P2Y Receptors: P2Y₁₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.