Within molecular and cell biology, p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.[1] It is also referred to as p84 and p87.[2] Some studies have found P87PIKAP to have a role in carcinogenesis.[3]
| Phosphoinositide-3-kinase adapter protein of 87 kDa | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | p87PIKAP | ||||||
| Alt. symbols | p84,PIK3R6 | ||||||
| NCBI gene | 146850 | ||||||
| HGNC | 27101 | ||||||
| OMIM | 611462 | ||||||
| UniProt | Q5UE93 | ||||||
| Other data | |||||||
| Locus | Chr. 17 p13.1 | ||||||
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References
edit- ^ Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
- ^ Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. Bibcode:2009PNAS..10620312K. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
- ^ Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737. S2CID 24708435.
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