Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.[5][6]

PACRG
Identifiers
AliasesPACRG, GLUP, HAK005771, PARK2CRG, PARK2 co-regulated, PARK2 coregulated, parkin coregulated, PACRG2.1
External IDsOMIM: 608427; MGI: 1916560; HomoloGene: 16212; GeneCards: PACRG; OMA:PACRG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080378
NM_001080379
NM_152410

NM_027032

RefSeq (protein)

NP_001073847
NP_001073848
NP_689623

NP_081308

Location (UCSC)Chr 6: 162.73 – 163.32 MbChr 17: 10.62 – 11.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112530Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037196Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ West AB, Lockhart PJ, O'Farell C, Farrer MJ (Jan 2003). "Identification of a novel gene linked to parkin via a bi-directional promoter". Journal of Molecular Biology. 326 (1): 11–9. doi:10.1016/S0022-2836(02)01376-1. PMID 12547187.
  6. ^ a b "Entrez Gene: PACRG PARK2 co-regulated".

Further reading

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