PANK4

Pantothenate kinase 4 is an enzyme (pantothenate kinase) that in humans is encoded by the PANK4 gene.

PANK4
Identifiers
Aliases	PANK4, pantothenate kinase 4, pantothenate kinase 4 (inactive), CTRCT49
External IDs	OMIM: 606162; MGI: 2387466; HomoloGene: 41235; GeneCards: PANK4; OMA:PANK4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.32 Start 2,508,537 bp End 2,526,597 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 E2 Start 155,048,580 bp End 155,065,395 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right hemisphere of cerebellum blood granulocyte gastrocnemius muscle skeletal muscle tissue left ventricle right auricle muscle of thigh pituitary gland Top expressed in neural layer of retina interventricular septum extraocular muscle otic vesicle digastric muscle vastus lateralis muscle soleus muscle temporal muscle retinal pigment epithelium muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding pantothenate kinase activity ATP binding kinase activity Cellular component cytoplasm Biological process coenzyme A biosynthetic process phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55229 269614 Ensembl ENSG00000157881 ENSG00000273494 ENSMUSG00000029056 UniProt Q9NVE7 Q80YV4 RefSeq (mRNA) NM_018216 NM_172990 NM_001305804 RefSeq (protein) NP_060686 NP_001292733 NP_766578 NP_001392980 NP_001392981 NP_001392982 NP_001392983 NP_001392984 NP_001392985 Location (UCSC) Chr 1: 2.51 – 2.53 Mb Chr 4: 155.05 – 155.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.

See also

• Pantothenate

Further reading

• Robishaw JD, Neely JR (1985). "Coenzyme A metabolism". Am. J. Physiol. 248 (1 Pt 1): E1–9. doi:10.1152/ajpendo.1985.248.1.E1. PMID 2981478.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Li Y, Chang Y, Zhang L, et al. (2005). "High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2)". Mol. Cell. Biochem. 277 (1–2): 117–25. doi:10.1007/s11010-005-5535-1. PMID 16132722. S2CID 34385941.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.