Pantothenate kinase 4 is an enzyme (pantothenate kinase) that in humans is encoded by the PANK4 gene.[5][6]

PANK4
Identifiers
AliasesPANK4, pantothenate kinase 4, pantothenate kinase 4 (inactive), CTRCT49
External IDsOMIM: 606162; MGI: 2387466; HomoloGene: 41235; GeneCards: PANK4; OMA:PANK4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018216

NM_172990
NM_001305804

RefSeq (protein)

NP_060686

Location (UCSC)Chr 1: 2.51 – 2.53 MbChr 4: 155.05 – 155.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.[6]

See also

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References

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  1. ^ a b c ENSG00000273494 GRCh38: Ensembl release 89: ENSG00000157881, ENSG00000273494Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029056Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ (Jul 2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594. S2CID 20400095.
  6. ^ a b "Entrez Gene: PANK4 pantothenate kinase 4".

Further reading

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