PAPOLG

Poly(A) polymerase gamma is an enzyme that in humans is encoded by the PAPOLG gene.

PAPOLG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LT6
Identifiers
Aliases	PAPOLG, poly(A) polymerase gamma
External IDs	OMIM: 616865; MGI: 2442119; HomoloGene: 56959; GeneCards: PAPOLG; OMA:PAPOLG - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p16.1 Start 60,756,253 bp End 60,802,086 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A3.2 Start 23,812,646 bp End 23,845,253 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell testicle Brodmann area 23 gonad ganglionic eminence buccal mucosa cell ventricular zone primary visual cortex tibia thyroid gland Top expressed in secondary oocyte zygote atrioventricular valve primary oocyte endocardial cushion genital tubercle medullary collecting duct mandibular prominence maxillary prominence pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding nucleotidyltransferase activity polynucleotide adenylyltransferase activity ATP binding metal ion binding RNA binding Cellular component membrane nucleus nucleoplasm cytosol nuclear body Biological process mRNA polyadenylation mRNA processing RNA polyadenylation RNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64895 216578 Ensembl ENSG00000115421 ENSMUSG00000020273 UniProt Q9BWT3 Q6PCL9 RefSeq (mRNA) NM_022894 NM_172555 RefSeq (protein) NP_075045 NP_766143 Location (UCSC) Chr 2: 60.76 – 60.8 Mb Chr 11: 23.81 – 23.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Topalian SL, Kaneko S, Gonzales MI, et al. (2001). "Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors". Mol. Cell. Biol. 21 (16): 5614–23. doi:10.1128/MCB.21.16.5614-5623.2001. PMC 87282. PMID 11463842.
• Kyriakopoulou CB, Nordvarg H, Virtanen A (2001). "A novel nuclear human poly(A) polymerase (PAP), PAP gamma". J. Biol. Chem. 276 (36): 33504–11. doi:10.1074/jbc.M104599200. PMID 11431479.
• Perumal K, Sinha K, Henning D, Reddy R (2001). "Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme". J. Biol. Chem. 276 (24): 21791–6. doi:10.1074/jbc.M101905200. PMID 11287430.
• Weichs an der Glon C, Ashe M, Eggermont J, Proudfoot NJ (1993). "Tat-dependent occlusion of the HIV poly(A) site". EMBO J. 12 (5): 2119–28. doi:10.1002/j.1460-2075.1993.tb05860.x. PMC 413433. PMID 8491200.