PAQR3

PAQR3
Identifiers
Aliases	PAQR3, RKTG, progestin and adipoQ receptor family member 3
External IDs	OMIM: 614577; MGI: 2679683; HomoloGene: 71077; GeneCards: PAQR3; OMA:PAQR3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	78,939,438 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	97,259,455 bp
RNA expression pattern
	Top expressed in
	sperm; ; jejunal mucosa; ; right testis; ; left testis; ; ganglionic eminence; ; testicle; ; skin of thigh; ; ventricular zone; ; Epithelium of choroid plexus; ; gonad;
	Top expressed in
	ganglionic eminence; ; lens; ; mesencephalon; ; hippocampus proper; ; rhombencephalon; ; dentate gyrus of hippocampal formation granule cell; ; striatum of neuraxis; ; cerebellum; ; neural tube; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; signaling receptor activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	negative regulation of protein phosphorylation; negative regulation of neuron projection development; MAPK cascade; negative regulation of MAP kinase activity; negative regulation of peptidyl-serine phosphorylation; protein localization to Golgi apparatus;
	Sources:Amigo / QuickGO
Orthologs
	152559
	231474
	ENSG00000163291
	ENSMUSG00000055725
	Q6TCH7
	Q6TCG8
	NM_001040202; NM_177453; NM_001350105; NM_001350106
	NM_198422; NM_001359910; NM_001359913
	NP_001035292; NP_001337034; NP_001337035
	NP_940814; NP_001346839; NP_001346842
	Wikidata
View/Edit Human	View/Edit Mouse

Progestin and adipoQ receptor family member 3 (PAQR3), or Raf Kinase Trapping to Golgi apparatus (RKTG) is a protein that in humans is encoded by the PAQR3 gene.^[5] It is a member of the progestin and adipoQ receptor (PAQR) family.^[6] PAQR3 is predicted to have seven transmembrane helices and to be localized to the Golgi Apparatus.^[7]^[8] It functions as a tumor suppressor by negatively regulating tumor cell proliferation and migration by inhibiting Raf kinase and AKT pathway.^[9]^[10]^[11]^[12]^[13] PAQR3 was also shown to modulate cholesterol homeostasis by anchoring the SCAP/SREBP complex to the Golgi under cholesterol depletion conditions.^[14]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163291 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055725 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yu X, Li Z, Chan MT, Wu WK (2015). "PAQR3: a novel tumor suppressor gene". American Journal of Cancer Research. 5 (9): 2562–2568. PMC 4633890. PMID 26609468.
^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–380. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
^ Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, et al. (September 2008). "Characterization of the topology and functional domains of RKTG". The Biochemical Journal. 414 (3): 399–406. doi:10.1042/BJ20080948. PMID 18547165.
^ Feng L, Xie X, Ding Q, Luo X, He J, Fan F, et al. (September 2007). "Spatial regulation of Raf kinase signaling by RKTG". Proceedings of the National Academy of Sciences of the United States of America. 104 (36): 14348–14353. Bibcode:2007PNAS..10414348F. doi:10.1073/pnas.0701298104. PMC 1964828. PMID 17724343.
^ Xie X, Zhang Y, Jiang Y, Liu W, Ma H, Wang Z, et al. (August 2008). "Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse". Carcinogenesis. 29 (8): 1632–1638. doi:10.1093/carcin/bgn139. PMID 18550569.
^ Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, et al. (September 2010). "RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma". Oncogene. 29 (39): 5404–5415. doi:10.1038/onc.2010.270. PMID 20603618.
^ Jiang Y, Xie X, Li Z, Wang Z, Zhang Y, Ling ZQ, et al. (April 2011). "Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition". Cancer Research. 71 (8): 2959–2968. doi:10.1158/0008-5472.CAN-10-4077. PMID 21385899.
^ Wang X, Li X, Fan F, Jiao S, Wang L, Zhu L, et al. (November 2012). "PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers". Carcinogenesis. 33 (11): 2228–2235. doi:10.1093/carcin/bgs245. PMID 22828136.
^ Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, et al. (June 2008). "RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells". Carcinogenesis. 29 (6): 1157–1163. doi:10.1093/carcin/bgn119. PMID 18515281.
^ Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, et al. (August 2015). "PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus". Nature Communications. 6 (1): 8100. Bibcode:2015NatCo...6.8100X. doi:10.1038/ncomms9100. PMC 4560833. PMID 26311497.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163291 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055725 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Yu_2015-5] Yu X, Li Z, Chan MT, Wu WK (2015). "PAQR3: a novel tumor suppressor gene". American Journal of Cancer Research. 5 (9): 2562–2568. PMC 4633890. PMID 26609468.

[TangHu2005-6] Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–380. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.

[7] Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, et al. (September 2008). "Characterization of the topology and functional domains of RKTG". The Biochemical Journal. 414 (3): 399–406. doi:10.1042/BJ20080948. PMID 18547165.

[8] Feng L, Xie X, Ding Q, Luo X, He J, Fan F, et al. (September 2007). "Spatial regulation of Raf kinase signaling by RKTG". Proceedings of the National Academy of Sciences of the United States of America. 104 (36): 14348–14353. Bibcode:2007PNAS..10414348F. doi:10.1073/pnas.0701298104. PMC 1964828. PMID 17724343.

[9] Xie X, Zhang Y, Jiang Y, Liu W, Ma H, Wang Z, et al. (August 2008). "Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse". Carcinogenesis. 29 (8): 1632–1638. doi:10.1093/carcin/bgn139. PMID 18550569.

[10] Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, et al. (September 2010). "RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma". Oncogene. 29 (39): 5404–5415. doi:10.1038/onc.2010.270. PMID 20603618.

[11] Jiang Y, Xie X, Li Z, Wang Z, Zhang Y, Ling ZQ, et al. (April 2011). "Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition". Cancer Research. 71 (8): 2959–2968. doi:10.1158/0008-5472.CAN-10-4077. PMID 21385899.

[12] Wang X, Li X, Fan F, Jiao S, Wang L, Zhu L, et al. (November 2012). "PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers". Carcinogenesis. 33 (11): 2228–2235. doi:10.1093/carcin/bgs245. PMID 22828136.

[13] Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, et al. (June 2008). "RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells". Carcinogenesis. 29 (6): 1157–1163. doi:10.1093/carcin/bgn119. PMID 18515281.

[14] Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, et al. (August 2015). "PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus". Nature Communications. 6 (1): 8100. Bibcode:2015NatCo...6.8100X. doi:10.1038/ncomms9100. PMC 4560833. PMID 26311497.

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