PBX3

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.

PBX3
Identifiers
Aliases	PBX3, PBX homeobox 3
External IDs	OMIM: 176312; MGI: 97496; HomoloGene: 21243; GeneCards: PBX3; OMA:PBX3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q33.3 Start 125,747,345 bp End 125,967,377 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 B|2 22.84 cM Start 34,061,469 bp End 34,263,154 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right adrenal cortex right ovary left adrenal cortex muscle layer of sigmoid colon right auricle internal globus pallidus C1 segment gallbladder vena cava Top expressed in Rostral migratory stream epithelium of lens substantia nigra olfactory bulb dorsal striatum ciliary body retinal pigment epithelium dorsal tegmental nucleus adrenal gland external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific protein binding Cellular component nucleus transcription regulator complex Biological process regulation of respiratory gaseous exchange by nervous system process adult locomotory behavior anterior compartment pattern formation dorsal spinal cord development neuron development regulation of transcription, DNA-templated transcription by RNA polymerase II posterior compartment specification respiratory gaseous exchange by respiratory system positive regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5090 18516 Ensembl ENSG00000167081 ENSMUSG00000038718 UniProt P40426 Q96AL5 O35317 RefSeq (mRNA) NM_001134778 NM_006195 NM_001330782 NM_001290576 NM_016768 RefSeq (protein) NP_001128250 NP_001317711 NP_006186 NP_006186.1 NP_001277505 NP_058048 Location (UCSC) Chr 9: 125.75 – 125.97 Mb Chr 2: 34.06 – 34.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Lu Q, Wright DD, Kamps MP (1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Mol. Cell. Biol. 14 (6): 3938–48. doi:10.1128/mcb.14.6.3938. PMC 358760. PMID 7910944.
• Shen WF, Rozenfeld S, Kwong A, et al. (1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. 19 (4): 3051–61. doi:10.1128/mcb.19.4.3051. PMC 84099. PMID 10082572.
• Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
• Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (2001). "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation". Oncogene. 20 (39): 5440–8. doi:10.1038/sj.onc.1204710. PMID 11571641.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Rhee JW, Arata A, Selleri L, et al. (2004). "Pbx3 Deficiency Results in Central Hypoventilation". Am. J. Pathol. 165 (4): 1343–50. doi:10.1016/S0002-9440(10)63392-5. PMC 1618620. PMID 15466398.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• PBX3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook Pbx3

This article incorporates text from the United States National Library of Medicine, which is in the public domain.