PCTK2

CDK17
Identifiers
Aliases	CDK17, PCTAIRE2, PCTK2, cyclin-dependent kinase 17, cyclin dependent kinase 17
External IDs	OMIM: 603440; MGI: 97517; HomoloGene: 55666; GeneCards: CDK17; OMA:CDK17 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	96,400,480 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	93,267,071 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Region I of hippocampus proper; ; Brodmann area 23; ; external globus pallidus; ; Achilles tendon; ; visceral pleura; ; postcentral gyrus; ; vena cava; ; superior frontal gyrus; ; middle temporal gyrus;
	Top expressed in
	olfactory tubercle; ; Region I of hippocampus proper; ; piriform cortex; ; nucleus accumbens; ; subiculum; ; primary motor cortex; ; temporal lobe; ; amygdala; ; prefrontal cortex; ; anterior amygdaloid area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein binding; ATP binding; kinase activity; cyclin-dependent protein serine/threonine kinase activity; protein serine/threonine kinase activity;
Cellular component	nucleus; cytoplasm;
Biological process	protein phosphorylation; phosphorylation; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5128
	237459
	ENSG00000059758
	ENSMUSG00000020015
	Q00537
	Q8K0D0
	NM_001170464; NM_002595
	NM_146239
	NP_001163935; NP_002586
	NP_666351
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the CDK17 gene.^[5]^[6]

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to rat protein which is thought to play a role in terminally differentiated neurons.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000059758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020015 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hirose T, Tamaru T, Okumura N, Nagai K, Okada M (Dec 1997). "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons". Eur J Biochem. 249 (2): 481–8. doi:10.1111/j.1432-1033.1997.t01-1-00481.x. PMID 9370357.
^ ^a ^b "Entrez Gene: PCTK2 PCTAIRE protein kinase 2".

Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.
Hirose T, Kawabuchi M, Tamaru T, Okumura N, Nagai K, Okada M (2000). "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain". Eur. J. Biochem. 267 (7): 2113–21. doi:10.1046/j.1432-1327.2000.01218.x. PMID 10727952.
Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. doi:10.1006/bbrc.2001.5493. PMID 11527406.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Keri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000059758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020015 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9370357-5] Hirose T, Tamaru T, Okumura N, Nagai K, Okada M (Dec 1997). "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons". Eur J Biochem. 249 (2): 481–8. doi:10.1111/j.1432-1033.1997.t01-1-00481.x. PMID 9370357.

[entrez-6] "Entrez Gene: PCTK2 PCTAIRE protein kinase 2".

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[6]

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PCTK2

References

Further reading