PDB may refer to:
- Bangladesh Power Development Board
- Chess Problem Database Server (PDB Server)
- 1,4-Dichlorobenzene (paradichlorobenzene)
- Party of German-speaking Belgians, (German: Partei der deutschsprachigen Belgier), a political party and predecessor of the ProDG
- PDB (Palm OS), a container format for record databases in Palm OS, Garnet OS and Access Linux Platform
- Pee Dee Belemnite, a standard for stable Carbon-13 and Oxygen-18 isotopes; see δ13C § Reference standard
- Pluggable database, such as an Oracle Database in a multitenancy environment
- Potato dextrose broth, a common microbiological growth media
- Pousette-Dart Band
- President's Daily Brief or Briefing or Bulletin, a top-secret intelligence document produced each morning for the U.S. President
- Program database, a file format for storing debugging information
- Promised Day Brigade, an Iraqi Shia organisation
- Protein Data Bank
- Protein Data Bank (file format)
- Python Debugger, see Python (programming language)