PDCD7

Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD7 gene.

PDCD7
Identifiers
Aliases	PDCD7, ES18, HES18, programmed cell death 7, 59K
External IDs	OMIM: 608138; MGI: 1859170; HomoloGene: 4170; GeneCards: PDCD7; OMA:PDCD7 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q22.31 Start 65,117,379 bp End 65,133,808 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 C Start 65,253,386 bp End 65,266,925 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell nipple superior surface of tongue tendon of biceps brachii thymus external globus pallidus nasal epithelium tail of epididymis medulla oblongata Top expressed in primary oocyte secondary oocyte zygote spermatocyte neural layer of retina muscle of thigh epiblast soleus muscle genital tubercle corneal stroma More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10081 50996 Ensembl ENSG00000090470 ENSMUSG00000041837 UniProt Q8N8D1 Q9WTY1 RefSeq (mRNA) NM_005707 NM_016688 RefSeq (protein) NP_005698 n/a Location (UCSC) Chr 15: 65.12 – 65.13 Mb Chr 9: 65.25 – 65.27 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein with sequence similarity to a mouse protein originally identified in embryonic stem cells. In mouse T-cell lines, this protein appears to be related to glucocorticoid- and staurine-induced apoptotic pathways, and to be linked to ceramide-mediated signalling. These observations suggest that this gene product is involved in specific apoptotic processes in T-cells.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• PDCD7 human gene location in the UCSC Genome Browser.
• PDCD7 human gene details in the UCSC Genome Browser.