PDE2A

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.

PDE2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB
Identifiers
Aliases	PDE2A, CGS-PDE, PDE2A1, PED2A4, cGSPDE, phosphodiesterase 2A, IDDPADS
External IDs	OMIM: 602658; MGI: 2446107; HomoloGene: 1952; GeneCards: PDE2A; OMA:PDE2A - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.4 Start 72,576,141 bp End 72,674,591 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right frontal lobe prefrontal cortex dorsolateral prefrontal cortex cingulate gyrus anterior cingulate cortex Brodmann area 9 orbitofrontal cortex Region I of hippocampus proper nucleus accumbens n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding 3',5'-cyclic-nucleotide phosphodiesterase activity calcium channel activity cGMP binding metal ion binding cyclic-nucleotide phosphodiesterase activity protein binding phosphoric diester hydrolase activity TPR domain binding hydrolase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cAMP binding protein homodimerization activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity identical protein binding magnesium ion binding zinc ion binding phosphate ion binding Cellular component cytoplasm cytosol Golgi apparatus membrane plasma membrane endoplasmic reticulum mitochondrion perinuclear region of cytoplasm presynaptic membrane nucleus mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrix Biological process establishment of endothelial barrier cellular response to transforming growth factor beta stimulus positive regulation of inflammatory response cellular response to cGMP negative regulation of transcription by RNA polymerase II monocyte differentiation cGMP-mediated signaling cellular response to macrophage colony-stimulating factor stimulus cellular response to mechanical stimulus positive regulation of vascular permeability cellular response to granulocyte macrophage colony-stimulating factor stimulus cAMP-mediated signaling signal transduction negative regulation of vascular permeability cGMP catabolic process cAMP catabolic process calcium ion transmembrane transport G protein-coupled receptor signaling pathway negative regulation of cAMP-mediated signaling cellular response to cAMP cellular response to 2,3,7,8-tetrachlorodibenzodioxine adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway positive regulation of gene expression negative regulation of cGMP-mediated signaling regulation of mitochondrion organization heart valve development ventricular septum development aorta development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5138 207728 Ensembl ENSG00000186642 ENSMUSG00000030653 UniProt O00408 Q922S4 RefSeq (mRNA) NM_001143839 NM_001146209 NM_001243784 NM_002599 NM_001008548 NM_001143848 NM_001143849 NM_001243757 NM_001243758 RefSeq (protein) NP_001137311 NP_001139681 NP_001230713 NP_002590 NP_001008548 NP_001137320 NP_001137321 NP_001230686 NP_001230687 Location (UCSC) Chr 11: 72.58 – 72.67 Mb n/a PubMed search
Wikidata
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Further reading

• Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, Van Laak V (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. 37 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892. S2CID 1060183.
• Seybold J, Thomas D, Witzenrath M, Boral S, Hocke AC, Bürger A, Hatzelmann A, Tenor H, Schudt C (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood. 105 (9): 3569–3576. doi:10.1182/blood-2004-07-2729. PMID 15650061.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. Bibcode:2002PNAS...9913260M. doi:10.1073/pnas.192374899. PMC 130621. PMID 12271124.
• Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. doi:10.1055/s-0037-1613099. PMID 12038792. S2CID 4637804.
• Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
• Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi:10.1177/002215549904700707. PMID 10375378.