PDLIM2

PDZ and LIM domain protein 2 is a protein that in humans is encoded by the PDLIM2 gene.

PDLIM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PA1, 3PDV
Identifiers
Aliases	PDLIM2, MYSTIQUE, SLIM, PDZ and LIM domain 2
External IDs	OMIM: 609722; MGI: 2384850; HomoloGene: 11006; GeneCards: PDLIM2; OMA:PDLIM2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.3 Start 22,578,279 bp End 22,598,025 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D2 Start 70,401,667 bp End 70,415,130 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen mucosa of pharynx skin of leg ascending aorta skin of abdomen Descending thoracic aorta right coronary artery stromal cell of endometrium nipple tibial nerve Top expressed in esophagus lip granulocyte right lung intestinal villus right lung lobe calvaria primary oocyte left lung left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding actin binding muscle alpha-actinin binding Cellular component cytoplasm cytoskeleton nucleus stress fiber Z discdkac filamentous actin Biological process heart development actin cytoskeleton organization muscle structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64236 213019 Ensembl ENSG00000120913 ENSMUSG00000022090 UniProt Q96JY6 Q8R1G6 RefSeq (mRNA) NM_198042 NM_021630 NM_176871 NM_001368120 NM_001253736 NM_145978 RefSeq (protein) NP_067643 NP_789847 NP_932159 NP_001355049 NP_001240665 NP_666090 Location (UCSC) Chr 8: 22.58 – 22.6 Mb Chr 14: 70.4 – 70.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Loughran G, Healy NC, Kiely PA, et al. (2005). "Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth". Mol. Biol. Cell. 16 (4): 1811–22. doi:10.1091/mbc.E04-12-1052. PMC 1073663. PMID 15659642.
• Tanaka T, Grusby MJ, Kaisho T (2007). "PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit". Nat. Immunol. 8 (6): 584–91. doi:10.1038/ni1464. PMID 17468759. S2CID 13357628.