PDZK1IP1

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PDZK1-interacting protein 1 is a protein that in humans is encoded by the PDZK1IP1 gene.^[5]^[6]^[7]^[8]^[9]

PDZK1IP1

Identifiers

PDZK1IP1, DD96, MAP17, SPAP, PDZK1 interacting protein 1

External IDs

OMIM: 607178; MGI: 1914432; HomoloGene: 4213; GeneCards: PDZK1IP1; OMA:PDZK1IP1 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p33	Start	47,183,582 bp^[1]
Band	1p33	End	47,191,044 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D1	Start	114,945,905 bp^[2]
Band	4\|4 D1	End	114,951,096 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

metanephric glomerulus

minor salivary glands

kidney tubule

palpebral conjunctiva

skin of abdomen

gallbladder

human kidney

skin of leg

gums

body of pancreas

Top expressed in

right kidney

human kidney

proximal tubule

corneal stroma

esophagus

medullary collecting duct

lip

conjunctival fornix

gastrula

left colon

More reference expression data


More reference expression data

Species

Human

Mouse


10158


67182


ENSG00000162366


ENSMUSG00000028716


Q13113


Q9CQH0

RefSeq (mRNA)


NM_005764


NM_001164557 NM_001164558 NM_026018

RefSeq (protein)


NP_005755


NP_001158029 NP_001158030 NP_080294

Location (UCSC)

Chr 1: 47.18 – 47.19 Mb

Chr 4: 114.95 – 114.95 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Interactions

PDZK1IP1 has been shown to interact with PDZK1.^[7]^[8]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162366 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028716 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kocher O, Cheresh P, Brown LF, Lee SW (Feb 1999). "Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique". Clin. Cancer Res. 1 (10): 1209–15. PMID 9815914.
^ Kocher O, Cheresh P, Lee SW (Sep 1996). "Identification and partial characterization of a novel membrane-associated protein (MAP17) up-regulated in human carcinomas and modulating cell replication and tumor growth". Am. J. Pathol. 149 (2): 493–500. PMC 1865305. PMID 8701988.
^ ^a ^b Silver DL, Wang N, Vogel S (Jul 2003). "Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels". J. Biol. Chem. 278 (31): 28528–32. doi:10.1074/jbc.M304109200. PMID 12754212.
^ ^a ^b Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H (Sep 2003). "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. 285 (4): F784-91. doi:10.1152/ajprenal.00109.2003. PMID 12837682. S2CID 25450845.
^ "Entrez Gene: PDZK1IP1 PDZK1 interacting protein 1".
^ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

Further reading

Kocher O, Comella N, Tognazzi K, Brown LF (1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab. Invest. 78 (1): 117–25. PMID 9461128.
Göttgens B, Barton LM, Chapman MA, Sinclair AM, Knudsen B, Grafham D, Gilbert JG, Rogers J, Bentley DR, Green AR (2002). "Transcriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL loci". Genome Res. 12 (5): 749–59. doi:10.1101/gr.45502. PMC 186570. PMID 11997341.
Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Guijarro MV, Castro ME, Romero L, Moneo V, Carnero A (2007). "Large scale genetic screen identifies MAP17 as protein bypassing TNF-induced growth arrest". J. Cell. Biochem. 101 (1): 112–21. doi:10.1002/jcb.21163. PMID 17230460. S2CID 20793096.
Guijarro MV, Leal JF, Fominaya J, Blanco-Aparicio C, Alonso S, Lleonart M, Castellvi J, Ruiz L, Ramon y Cajal S, Carnero A (2007). "MAP17 overexpression is a common characteristic of carcinomas". Carcinogenesis. 28 (8): 1646–52. doi:10.1093/carcin/bgm083. PMID 17426052.
Guijarro MV, Leal JF, Blanco-Aparicio C, Alonso S, Fominaya J, Lleonart M, Castellvi J, Ramon y Cajal S, Carnero A (2007). "MAP17 enhances the malignant behavior of tumor cells through ROS increase". Carcinogenesis. 28 (10): 2096–104. doi:10.1093/carcin/bgm124. PMID 17548903.

External links

PDZK1IP1 human gene location in the UCSC Genome Browser.
PDZK1IP1 human gene details in the UCSC Genome Browser.

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