Protein pelota homolog is a protein that in humans is encoded by the PELO gene.[5][6]

PELO
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPELO, PRO1770, CGI-17, pelota homolog (Drosophila), pelota mRNA surveillance and ribosome rescue factor
External IDsOMIM: 605757; MGI: 2145154; HomoloGene: 6835; GeneCards: PELO; OMA:PELO - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015946

NM_134058

RefSeq (protein)

NP_057030

NP_598819

Location (UCSC)Chr 5: 52.79 – 52.8 MbChr 13: 115.22 – 115.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.[6] In yeasts, the Dom34-Hbs1 complex (with ABCE1) that it forms is responsible for reactivating ribosomes and for recovering those stuck on mRNAs.[7] It is a paralog of the release factor eRF1.

The Drosophila homolog was first discovered in 1993. Mutants exhibit G2/M arrest in meiosis and large nebenkern form in late spermatocytes.[8] Human, yeast (Dom34), plant, and worm homologs are reported in 1995,[9] followed by one found in archaea.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152684Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042275Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shamsadin R, Adham IM, von Beust G, Engel W (Nov 2000). "Molecular cloning, expression and chromosome location of the human pelota gene PELO". Cytogenetics and Cell Genetics. 90 (1–2): 75–8. doi:10.1159/000015667. PMID 11060452. S2CID 35316587.
  6. ^ a b "Entrez Gene: PELO pelota homolog (Drosophila)".
  7. ^ van den Elzen AM, Schuller A, Green R, Séraphin B (February 2014). "Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress". The EMBO Journal. 33 (3): 265–76. doi:10.1002/embj.201386123. PMC 3989619. PMID 24424461.
  8. ^ Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, et al. (October 1993). "Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis". Genetics. 135 (2): 489–505. doi:10.1093/genetics/135.2.489. PMC 1205651. PMID 8244010.
  9. ^ Eberhart CG, Wasserman SA (October 1995). "The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis". Development. 121 (10): 3477–86. doi:10.1242/dev.121.10.3477. PMID 7588080.
  10. ^ Ragan MA, Logsdon JM, Sensen CW, Charlebois RL, Doolittle WF (November 1996). "An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes". FEMS Microbiology Letters. 144 (2–3): 151–5. doi:10.1111/j.1574-6968.1996.tb08522.x. PMID 8900058.

Further reading

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