PES1

Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.

PES1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EP8
Identifiers
Aliases	PES1, PES, pescadillo ribosomal biogenesis factor 1, NOP7
External IDs	OMIM: 605819; MGI: 1890613; HomoloGene: 5984; GeneCards: PES1; OMA:PES1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.2 Start 30,576,625 bp End 30,607,083 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A1 Start 3,913,975 bp End 3,930,004 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve body of pancreas islet of Langerhans skin of leg mucosa of transverse colon skin of abdomen left testis stromal cell of endometrium body of stomach right testis Top expressed in interventricular septum yolk sac spermatocyte ventricular zone neural layer of retina tail of embryo spermatid otic vesicle embryo epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding ribonucleoprotein complex binding Cellular component membrane PeBoW complex chromosome nucleolus condensed chromosome nucleus nucleoplasm cytosol preribosome, large subunit precursor Biological process protein localization to organelle ribosome biogenesis regulation of cell cycle nucleolus organization maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cell population proliferation rRNA processing maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal large subunit biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23481 64934 Ensembl ENSG00000100029 ENSMUSG00000020430 UniProt O00541 Q9EQ61 RefSeq (mRNA) NM_001243225 NM_001282327 NM_001282328 NM_014303 NM_022889 RefSeq (protein) NP_001230154 NP_001269256 NP_001269257 NP_055118 NP_075027 Location (UCSC) Chr 22: 30.58 – 30.61 Mb Chr 11: 3.91 – 3.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.

Further reading

• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Kinoshita Y, Jarell AD, Flaman JM, et al. (2001). "Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells". J. Biol. Chem. 276 (9): 6656–65. doi:10.1074/jbc.M008536200. PMID 11071894.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Oeffinger M, Leung A, Lamond A, et al. (2002). "Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis". RNA. 8 (5): 626–36. doi:10.1017/S1355838202020022. PMC 1370283. PMID 12022229.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lapik YR, Fernandes CJ, Lau LF, Pestov DG (2004). "Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis". Mol. Cell. 15 (1): 17–29. doi:10.1016/j.molcel.2004.05.020. PMID 15225545.
• Maiorana A, Tu X, Cheng G, Baserga R (2004). "Role of pescadillo in the transformation and immortalization of mammalian cells". Oncogene. 23 (42): 7116–24. doi:10.1038/sj.onc.1207916. PMID 15273728.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Killian A, Le Meur N, Sesboüé R, et al. (2004). "Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability". Oncogene. 23 (53): 8597–602. doi:10.1038/sj.onc.1207845. PMID 15467761. S2CID 7435460.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Hölzel M, Rohrmoser M, Schlee M, et al. (2005). "Mammalian WDR12 is a novel member of the Pes1–Bop1 complex and is required for ribosome biogenesis and cell proliferation". J. Cell Biol. 170 (3): 367–78. doi:10.1083/jcb.200501141. PMC 2171466. PMID 16043514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.